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. 2017 Jun 21;8:391. doi: 10.3389/fphar.2017.00391

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Copyright © 2017 Genaro, Fabris, Arantes, Zuardi, Crippa and Prado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cannabidiol induced significant CPP in incised but not sham rats. (A) Timeline of the protocol for the experiments; (B) CBD (1 mg/kg; n = 13) produced significant CPP only in incised rats. One-way ANOVA with Tukey’s test: ^∗p < 0.05 compared with sham-incised groups and vehicle-treated incised group. Data are means ± SEMs. The insert shows that intraperitoneal (i.p.) administration of vehicle (VEH; n = 11) or CBD (1 mg/kg; n = 10) in sham-incised rats as well as vehicle (n = 12) in incised rats produced no significant effect on the WT. Arrows 1 and 2 indicate the times of surgery and injection, respectively.