Table 2.

Univariate and multivariate Cox regression demonstrating factors associated with cardiovascular-event risk. Variables with P values < .05 on univariate analysis were candidates for stepwise multivariate analysis.

	Univariate Analysis		Multivariate Analysis
	Hazard Ratio (95% CI)	P Value	Hazard Ratio (95% CI)	P Value
Age (≥ 68 vs. <68)	1.40 (1.13–1.72)	.002**	1.29 (1.04–1.59)	0.02*
Hypertension	1.38 (1.12–1.70)	.002**
Hyperlipidemia	1.38 (1.10–1.73)	.005**
Diabetes mellitus	1.80 (1.33–2.44)	.0001***	1.69 (1.25–2.29)	0.0007***
Prior cardiovascular event	2.28 (1.80–2.88)	<.0001***	2.15 (1.70–2.73)	< 0.0001***
Smoking history
0–20 pack-years	Reference	N/A	Reference	N/A
>20 pack-years	1.51 (1.17–1.95)	0.002**	1.42 (1.10–1.84)	0.0007***
Unknown	1.33 (1.04–1.71)	0.02*	1.37 (1.06–1.76)	0.02*
NCCN risk group
Low	Reference	N/A
Intermediate	0.93 (0.72–1.19)	0.56
High	1.10 (0.84–1.44)	0.47
RT modality
EBRT alone	Reference	N/A
Brachytherapy alone	0.70 (0.50–0.98)	0.04*
EBRT + brachytherapy	0.71 (0.42–1.19)	0.20
ADT at the time of RT	1.35 (1.09–1.66)	0.005**	1.34 (1.09–1.65)	0.007**
Salvage ADT	1.74 (1.26–2.39)	0.0007***	1.77 (1.29–2.44)	0.0004***

ADT, androgen-deprivation therapy; AJCC, American Joint Committee on Cancer; CI, confidence interval; EBRT, external beam radiotherapy; NCCN, National Comprehensive Cancer Network; RT, radiotherapy.

The significance of corresponding P values is indicated as follows:

^*< .05;

^**< .01;

^***< .001.