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. 2005 Jan 21;102(5):1755–1760. doi: 10.1073/pnas.0409225102

Fig. 2.

Fig. 2.

Mechanical hypernociception induced by i.pl. injection of KC: the role of TNF-α, IL-1β, prostaglandins, and sympathomimetic amines. (A) Dose– and time–response curves of the hypernociception induced by i.pl. injection of KC (1, 3, and 10 pg per paw) or saline (SAL; control). The hypernociceptive effects were determined at 1, 3, and 5 h after the stimuli injection. (B) Nociceptive response induced by KC (10 ng per paw) in WT mice pretreated with 15 μlof saline (Sal) or TNF-R1–/– mice and pretreatment of WT mice with 500 ng of AbKC delivered i.pl., 500 ng of IL-1ra delivered i.pl, 5 mg/kg indomethacin (Indo) delivered i.p., 30 mg/kg guanethidine (Gua) delivered s.c., and indomethacin plus guanethidine. The hypernociceptive responses were taken 3 h after KC injection. The results are expressed as the mean ± SEM of five animals per group. *, Statistically significant different time points (P < 0.05); **, statistically significant difference compared with the control group (P < 0.05).