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Representative diagram of Cg-induced inflammatory hypernociceptive cytokine cascade in mice. Shown is the sequential release (solid line, stimulation) of inflammatory mediators initiated by Cg and intermediated by cytokines and the final induction by prostanoids (PGs) and sympathetic amines (SA). The cascade pharmacological and genetic approach susceptibility is also shown (dotted line, inhibition) along with the other possibilities for TNF-α action (question marks).
