Figure 3.

GABA_A α1β2γ2 receptor EC₅₀ determination for the agonist GABA. (A) Calculation of half-maximal receptor activation using seven different concentrations of the agonist (0.3–1,000 μM). The EC₅₀ was determined at 37 ± 0.4 μM GABA, while EC₁₀₋₃₀was calculated to 10 μM. (B) The black bar illustrates the mean relative current of GABA_A receptors α1β2γ2 at 10 μM GABA. Potentiation of GABAergic currents by linalool (2 mM) at EC₁₀₋₃₀GABA concentrations (10 μM) refers to the white bar, ^*P < 0.05; linalyl acetate (striped bar); n = number of cells recorded.