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. 2017 Jun 21;5:46. doi: 10.3389/fchem.2017.00046

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Copyright © 2017 Milanos, Elsharif, Janzen, Buettner and Villmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acetylated linalool derivatives do not potentiate GABAergic currents in HEK293 cells. Ten micromolars of GABA were applied to α1β2γ2 receptors and refers to 100% (100 ± 15% GABA application, black bar; relative to GABA + linalyl acetate). Acetylated linalool compounds such as linalyl acetate (striped bar), L1 (8-hydroxylinalyl acetate), L2 (8-oxolinalyl acetate), L3 (8-carboxylinalyl acetate) used in a 2 mM concentration were co-applied with GABA (gray bars), n = number of cells recorded.