TABLE 1.
DPGs commonly regulated by both mCAR and hCAR activation and at both developmental ages
Data are expressed as ratios of FPKM in the CAR ligand–treated group over the vehicle-treated group of the same age and genotype.
| Gene Symbol | WT (TCPOBOP/Corn Oil) |
hCAR-TG (CITCO/Corn Oil) |
||
|---|---|---|---|---|
| Day 5 | Day 60 | Day 5 | Day 60 | |
| Cyp1a2 | 5.72 | 2.90 | 6.48 | 1.99 |
| Cyp2b10 | 397.45 | 201.52 | 154.93 | 5.44 |
| Cyp2c29 | 215.63 | 6.98 | 73.99 | 1.83 |
| Cyp2c37 | 7.98 | 4.09 | 4.37 | 2.16 |
| Cyp2c50 | 33.58 | 4.74 | 22.84 | 2.07 |
| Cyp2c54 | 35.16 | 4.66 | 20.73 | 2.04 |
| Cyp2c55 | 284.18 | 124.01 | 7.98 | 14.05 |
| Cyp3a11 | 9.48 | 4.03 | 4.24 | 4.00 |
| Cyp3a13 | 5.24 | 2.44 | 1.48 | 1.70 |
| Cyp3a25 | 2.67 | 1.39 | 2.09 | 1.33 |
| Cyp4f15 | 3.14 | 1.89 | 1.50 | 1.42 |
| Por | 4.34 | 6.46 | 1.64 | 4.42 |
| Akr1b7 | 5.93 | 371.33 | 1.45 | 17.68 |
| Akr1c14 | 1.62 | 1.35 | 1.80 | 1.53 |
| Aldh1a1 | 23.59 | 2.80 | 5.96 | 1.76 |
| Aldh1a7 | 57.03 | 5.77 | 7.37 | 1.84 |
| Ces1d | 2.04 | 1.50 | 1.51 | 1.85 |
| Ces1g | 4.55 | 1.44 | 4.17 | 1.70 |
| Ces2a | 18.97 | 12.18 | 2.94 | 3.59 |
| Ephx1 | 6.37 | 5.00 | 1.97 | 2.78 |
| Fmo5 | 5.53 | 4.07 | 1.84 | 1.39 |
| Ugt2b34 | 3.50 | 3.39 | 1.52 | 1.77 |
| Ugt2b35 | 3.45 | 3.08 | 1.85 | 2.18 |
| Ugt2b36 | 3.66 | 1.94 | 1.53 | 1.56 |
| Sult1c2 | 3.59 | 13.44 | 1.57 | 3.28 |
| Sult1d1 | 2.54 | 2.87 | 2.00 | 1.68 |
| Sult5a1 | 10.98 | 1.63 | 1.86 | 1.40 |
| Gsta2 | 7.09 | 8.54 | 4.72 | 5.09 |
| Gstm1 | 12.39 | 12.74 | 2.05 | 4.81 |
| Gstm2 | 8.01 | 23.52 | 1.50 | 2.40 |
| Gstm3 | 127.97 | 192.51 | 3.09 | 16.06 |
| Gstt3 | 43.17 | 8.47 | 6.79 | 3.09 |
| Ptges | 53.61 | 42.97 | 3.74 | 4.12 |
| Inmt | 6.71 | 2.12 | 1.65 | 2.38 |
| Abcc3 | 16.53 | 3.62 | 2.56 | 2.22 |
| Abcc4 | 21.09 | 16.46 | 3.68 | 2.65 |