FIG 7.

Potential effects of propofol on host immunity against S. aureus infection. Upon infection with S. aureus, propofol treatment increases bacterial replication and abscess formation in the kidney. In the case of bloodstream S. aureus infection, while propofol does not affect the recruitment of blood monocytes into the kidney, it may prevent differentiation of monocytes to macrophages, allowing for greatly expanded inflammatory abscesses in the kidney. Propofol may also allow for the expansion of MDSCs, which can lead to reduced T cell activation.