Table 3.

Studies involving stress paradigms and Aβ production

Studies on Aβ	Model	Stress paradigm	Effect	Comments
Kang et al. (2007) [47]	Tg2576 [82]	3 months isolation	↑
Dong et al. (2008) [48]	Tg2576	6 months isolation	↑
Lee et al. (2009) [83]	Tg2576	2 h restraint daily for 16 days	↑	Measured ISF, soluble Aβ
Ray et al. (2011) [50]	Wistar rat	5 h restraint or bilateral UCN1 injection in amygdala	↑
Huang et al. (2011) [84]	APP/PS1 [85]	4 months isolation	↑
Rothman et al. (2012) [86]	3xTg AD [87]	Cage switched for 6 h/day for 2–3 days/week for 6 weeks	↑
Dong et al. (2012) [49]	Tg2576/ CRH overexpressing [88]	CRH overexpressing transgenic	↑
Rothman et al. (2013) [53]	3xTg AD	6 h sleep restriction for 6 weeks	-	Aβ and tau measures trending upward but non-significant
Dong et al. (2014) [43]	Tg2576	One week or 10 months of isolation	↑
Baglietto-Vargas et al. (2015) [89]	3xTg AD	5 h of multimodal stress. Brief restraint, shaker plate with bright lights and noise	↑
Park et al. (2015) [44]	C57BL/6 J	3 h restraint	↑
Justice et al. (2015) [90]	APP/PS1	PTSD-like induction for two hours followed by a trigger	↑

Studies in WT mice or rats observed levels of soluble Aβ42 and Aβ40 in brain homogenate, studies in transgenic mice included measurements of plaque load and insoluble Aβ unless noted otherwise