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Model of tau-tubulin fuzzy complexes. Tau contains multiple tubulin binding motifs (red circles) located in the MTBR (blue) and R′ (yellow). These motifs bind to tubulin or microtubules stochastically and dynamically. This mode of interaction allows tau to perform functional roles as a stabilizer, cross-linker, and recruiter. Variable combinations of binding motifs work cooperatively to stabilize microtubule and promote microtubule assembly.
