Table 1.
Distance Changes between Selected Pairs of Residues upon Activation
| Residue Pair | Domain Location | Distance change (Å) | Related Functional Motion upon Activation |
|---|---|---|---|
| S126N1-H171N1 | R1N1-R2N1 | 2 | intrasubunit R1-R2 opening |
| H101N1-H171N1 | R1N1-R2N1 | 3 | intrasubunit R1-R2 twisting |
| G200N1-E328N2A | R2N1-R1N2A | 5 | intradimer R1-R2 opening |
| A175N1-R181N2A | R2N1-R2N2A | −2 | intradimer R2-R2 closing |
| K178N1-S185N2A | R2N1-R2N2A | −3 | intradimer R2-R2 closing |
| Q696N1-G784N2A | D2N1-D1N2A | 1 | intradimer D1-D2 opening |
| E781N1-N697N2A | D1N1-D2N2A | −2 | intradimer D1-D2 closing |
| Y535N1-V783N2A | D1N1-D1N2A | −1 | intradimer D1-D1 closing |
| K669N2A-K669N2A | LBD-M3 linkers of N2A | 10 | outward pulling of LBD-M3 linkers in N2A |
| R671N1-R671N1 | LBD-M3 linkers of N1 | 0 | no pulling of LBD-M3 linkers in N1 |
| M823N2A-V635N1 | M4N2A-M3N1 | 2 | relative M3-M4 sliding |