Table 3. Interaction of Telomere Length and Certain Subsegmental Brain Regions by Agea.
| Subsegmental Brain Region | Age≤50y (n = 1013) | Age >50 y (n = 947) | P Value for Interaction | ||||
|---|---|---|---|---|---|---|---|
| β Level (SE) | P Value | Partial R2, % | β Level (SE) | P Value | Partial R2, % | ||
| Parietal | |||||||
| Inferior parietal | 0.02 (0.02) | .51 | NA | 0.13 (0.03) | <.001 | 2.78 | .001 |
| Superior parietal | 0.01 (0.02) | .71 | NA | 0.11 (0.03) | <.001 | 1.81 | .004 |
| Temporal | |||||||
| Hippocampus | 0.05 (0.02) | .07 | NA | 0.10 (0.03) | .004 | 1.28 | .04 |
| Fusiform | 0.03 (0.02) | .31 | NA | 0.09 (0.03) | .002 | 1.45 | .03 |
Abbreviation: NA, not applicable.
a
Covariates in the multivariable model include age, sex, race/ethnicity, telomere length, and total cranial volume. The effect size of telomere length (β level) is reported as the mean difference in each regional brain size associated with a 1-SD unit difference in telomere length. P values for the main effect of telomere length have been corrected for multiple comparisons.