Table 2.
Treatment Group | SRI baseline | SRI Dose baseline (mg/day) | Previous SRI trials | Total YBOCS – Baseline | Total YBOCS – Week 6 | Endpoint dose (mg/day) | % CHANGE | CGI – Improvement | Response status | |
Quetiapine | 1 | Paroxetine | 60 | 1 | 33 | 29 | 50 | -12.00 | 3 | N/R |
2 | Citalopram | 60 | 2 | 25 | 23 | 200 | -8.00 | 4 | N/R | |
3 | Fluvoxamine | 300 | 1 | 32 | 27 | 300 | -16.00 | 3 | N/R | |
4 | Citalopram | 70 | 1 | 27 | 25 | 25 (E/W)* | -7.00 | 4 | N/R | |
5 | Clomipramine | 250 | 2 | 22 | 27 | 100 | 23.00 | 5 | N/R | |
6 | Paroxetine | 60 | 5 | 35 | 32 | 300 | -9.00 | 4 | N/R | |
7 | Fluoxetine | 80 | 3 | 25 | 16 | 300 | -36.00 | 2 | R | |
8 | Sertraline | 200 | 1 | 18 | 3 | 50 | -83.00 | 1 | R | |
9 | Fluoxetine | 20 | 1 | 21 | 20 | 300 | -5.00 | 4 | N/R | |
10 | Fluoxetine | 60 | 1 | 22 | 17 | 300 | -23.00 | 2 | N/R | |
11 | Citalopram | 60 | 1 | 32 | 17 | 300 | -47.00 | 1 | R | |
12 | Fluoxetine | 80 | 1 | 32 | 14 | 300 | -56.00 | 1 | R | |
13 | Fluvoxamine | 300 | 1 | 30 | 12 | 50 | -60.00 | 1 | R | |
14 | Fluoxetine | 60 | 1 | 25 | 7 | 50 | -72.00 | 1 | R | |
15 | Citalopram | 60 | 1 | 27 | 24 | 200 | -11.00 | 4 | N/R | |
16 | Fluvoxamine | 300 | 1 | 24 | 12 | 150 | -50.00 | 2 | R | |
17 | Fluvoxamine | 200 | 2 | 22 | 22 | 50 | .00 | 4 | N/R | |
18 | Fluvoxamine | 300 | 2 | 25 | 22 | 25 | -12.00 | 4 | N/R | |
19 | Fluoxetine | 60 | 2 | 24 | 25 | 25 (E/W)* | 4.00 | 4 | N/R | |
20 | Clomipramine | 250 | 2 | 27 | 12 | 300 | -56.00 | 2 | R | |
Placebo | 1 | Fluvoxamine | 300 | 2 | 32 | 25 | 300 | -22.00 | 3 | N/R |
2 | Fluvoxamine | 300 | 1 | 30 | 28 | 300 | -7.00 | 3 | N/R | |
3 | Fluoxetine | 80 | 2 | 34 | 38 | 300 | 12.00 | 4 | N/R | |
4 | Paroxetine | 60 | 1 | 22 | 18 | 300 | -18.00 | 1 | N/R | |
5 | Citalopram | 60 | 1 | 28 | 26 | 300 | -7.00 | 4 | N/R | |
6 | Fluoxetine | 60 | 5 | 26 | 24 | 300 | -8.00 | 3 | N/R | |
7 | Fluoxetine | 60 | 1 | 23 | 23 | 300 | .00 | 4 | N/R | |
8 | Fluoxetine | 60 | 1 | 27 | 10 | 300 | -63.00 | 1 | R | |
9 | Fluoxetine | 40 | 1 | 32 | 18 | 300 | -44.00 | 2 | R | |
10 | Citalopram | 60 | 2 | 24 | 23 | 300 | -4.00 | 4 | N/R | |
11 | Citalopram | 60 | 1 | 35 | 23 | 300 | -34.00 | 2 | R | |
12 | Fluvoxamine | 300 | 3 | 22 | 14 | 300 | -36.00 | 2 | R | |
13 | Citalopram | 60 | 1 | 28 | 10 | 50 | -65.00 | 2 | R | |
14 | Fluoxetine | 60 | 1 | 28 | 4 | 50 | -86.00 | 2 | R | |
15 | Citalopram | 60 | 1 | 26 | 19 | 100 | -27.00 | 2 | R | |
16 | Fluoxetine | 60 | 1 | 27 | 12 | 100 | -56.00 | 1 | R | |
17 | Fluoxetine | 20 | 1 | 26 | 18 | 200 | -31.00 | 2 | R | |
18 | Fluvoxamine | 300 | 2 | 23 | 35 | 200 | 52.00 | 6 | N/R | |
19 | Citalopram | 60 | 2 | 26 | 9 | 100 | -65.00 | 2 | R | |
20 | Paroxetine | 80 | 1 | 32 | 29 | 300 | -9.00 | 3 | N/R | |
21 | Fluvoxamine | 300 | 3 | 31 | 25 | 100 | -19.00 | 2 | N/R |
*E/W = Early withdrawal