Figure 1.

Overview of our method for fitting Adenylate kinase. The atomic model (PDB: 4AKE, chain A) is fitted to a simulated density map (generated from PDB: 1AKE, chain A). Our inputs are marked in green dashed boxes, including the atomic model (a), the density map with detected α-helices (b), the correspondence between the model helices and map helices (shown by coloring in (a) and (b)), and the density skeleton of the map (c). Our method consists of two stages. Stage 1 deforms the C-α backbone, which proceeds by first fitting the backbone to the map helices (d) and then to the density skeleton (e). Stage 2 recovers the full-atom structure (f), which is the output, marked in the purple dashed box. To see this figure in color, go online.