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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Apr 8;27(11):2432–2438. doi: 10.1016/j.bmcl.2017.04.011

Scheme 1.

Scheme 1

Reagents and conditions: (a) LHMDS, THF, −78 °C to 25 °C, 46%; (b) H2, Pd(OH)2, EtOH, AcOH, 23 °C, 90%; (c) 11, or 12, EDCI, HOBt, DIPEA, CH2Cl2; 23 °C, 60%; (d) TFA, CH2Cl2, 23 °C, 80%.