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Reagents and conditions: (a) LHMDS, dry THF, −78 °C to 23 °C, then add aldehyde 7, 38%; (b) H2, Pd(OH)2, EtOH, AcOH 23 °C; (c) 11 or 18, EDCI, HOBt, DIPEA, CH2Cl2; 23 °C; (d) TFA, CH2Cl2, 23 °C, (31% over 3 steps); (e) BH3•SMe, dry THF, reflux, 78%.
