Table 1. MiRNAs Differentially Expressed in Myeloma and Carried by Exosomes with a Role in Adipose Tissue.

miRNAs of interest and reference	Upregulated or downregulated in MM	Role in adipose tissue (BMAT or WAT)	Reference demonstrating miR carried by exosomes
miR-15b [15]	Upregulated	Inhibits osteoblast differentiation [9]	[30]
miR-181b [6, 15–17, 25, 27]	Upregulated	Associated with inflammation in AT [36, 43]	[30]
miR-21 [6, 16, 17, 25, 26]	Upregulated	Adhesion to the BMME upregulates in myeloma cells, upregulated in obese WAT [6, 36]	[29]
miR-222 [17, 27]	Upregulated	Associated with inflammation in AT [36]	[29]
Let-15a [6]	Downregulated	Biomarker for type 2 diabetes and morbid obesity, inhibits adipogenic differentiation [36, 43]	[30]
Let-7 family (let-7a, let-7b-5p, let-7f, let-7g, let-7i) [6, 46, 56]	Downregulated	Downregulated in obese WAT, associated with inflammation in AT, all AT expresses let-7a-1-5p and let-7f-5p [36, 43]	[29, 30]