Table 3.
Correlation between serum IgG4 levels and clinical characteristics
| Clinical characteristics | Training cohort | Validation cohort | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of patients (N=195) | IgG4/IgG≤0.08 (N=169) |
IgG4/IgG>0.08 (N=26) |
P | No. of patients (N=100) | IgG4/IgG≤0.08 (N=82) |
IgG4/IgG>0.08 (N=18) |
P | |
| Age | ||||||||
| ≤50 | 60 | 48 | 12 | 0.068 | 46 | 39 | 7 | 0.504 |
| >50 | 135 | 121 | 14 | 54 | 43 | 11 | ||
| Sex | ||||||||
| Male | 172 | 147 | 25 | 0.177 | 81 | 66 | 15 | 1.000 |
| Female | 23 | 22 | 1 | 19 | 16 | 3 | ||
| AFP, ng/mL | ||||||||
| ≤400 | 139 | 121 | 18 | 0.804 | 68 | 55 | 13 | 0.672 |
| >400 | 56 | 48 | 8 | 32 | 27 | 5 | ||
| ALT, U/L | ||||||||
| ≤75 | 176 | 154 | 22 | 0.492 | 96 | 78 | 18 | 0.770 |
| >75 | 19 | 15 | 4 | 4 | 4 | 0 | ||
| HBsAg | ||||||||
| Negative | 12 | 11 | 1 | 0.930 | 18 | 15 | 3 | 1.000 |
| Positive | 183 | 158 | 25 | 82 | 67 | 15 | ||
| Liver cirrhosis | ||||||||
| No | 38 | 35 | 3 | 0.272 | 30 | 27 | 3 | 0.173 |
| Yes | 157 | 134 | 23 | 70 | 55 | 15 | ||
| No. of tumor | ||||||||
| Single | 150 | 132 | 18 | 0.453 | 85 | 71 | 14 | 0.560 |
| Multiple | 45 | 37 | 8 | 15 | 11 | 4 | ||
| Tumor size, cm | ||||||||
| ≤5 | 114 | 103 | 11 | 0.073 | 67 | 54 | 13 | 0.603 |
| >5 | 81 | 66 | 15 | 33 | 28 | 5 | ||
| Tumor encapsulation | ||||||||
| Complete | 124 | 105 | 19 | 0.280 | 59 | 51 | 8 | 0.166 |
| None | 71 | 64 | 7 | 41 | 31 | 10 | ||
| Satellite lesion | ||||||||
| No | 179 | 157 | 22 | 0.152 | 87 | 72 | 15 | 0.901 |
| Yes | 16 | 12 | 4 | 13 | 10 | 3 | ||
| Vascular invasion | ||||||||
| No | 123 | 107 | 16 | 0.861 | 57 | 46 | 11 | 0.697 |
| Yes | 72 | 62 | 10 | 43 | 36 | 7 | ||
| Edmondson stage | ||||||||
| I-II | 119 | 102 | 17 | 0.624 | 63 | 50 | 13 | 0.371 |
| III-IV | 76 | 67 | 9 | 37 | 32 | 5 | ||
| Child-Pugh score | ||||||||
| A | 189 | 164 | 25 | 1.000 | 97 | 80 | 17 | 1.000 |
| B | 6 | 5 | 1 | 3 | 2 | 1 | ||
| BCLC stage | ||||||||
| 0+A | 140 | 123 | 17 | 0.435 | 82 | 67 | 15 | 1.000 |
| B+C | 55 | 46 | 9 | 18 | 15 | 3 | ||
Abbreviations: AFP, α-fetoprotein; ALT, alanine aminotransferase; HBsAg, hepatitis B surface antigen; BCLC, Barcelona Clinic Liver Cancer. Vascular invasion contains both portal invasion and microvascular invasion.