Figure 5.
The anti-metastatic activity of NUP, cisplatin or both in vivo. C57BL/6 mice were given an intravenous injection of B16 melanoma cells (3*105 cells/200 μl PBS). (B) NUP (20 mg/kg), (C) cisplatin (4 mg/kg) or both (D) were given every other day from day 0 to day 14. Control animals received only vehicle (A). Lungs were excised on day 18. NUP in combination with cisplatin treatment reduced metastasis. The average and standard error was determined by densitometry of each group and the significance was determined by t-test (p<0.05 *, p<0.01 **). These results are representative of two similar independent experiments.