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. 2017 Jun 15;12:4455–4466. doi: 10.2147/IJN.S135735

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© 2017 Gong et al. This work is published and licensed by Dove Medical Press Limited

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The schematic of the optimized LFIA for BNP detection.

Notes: (A) The structure of previous LFA is adjusted by adding a conjugate pad to form a new type of LFIA. (B) The negative result (i) and positive result (ii) show the principle of the LFIA. (C) The diameter of GNP is adjusted from 13±3 to 35±3 nm. (D) The concentration of test line is adjusted from 0.5 to 1.5 mg/mL.

Abbreviations: GNP, gold nanoparticle; BNP, brain natriuretic peptide; LFA, lateral flow assay; LFIA, lateral flow immunoassay; NC, nitrocellulose.