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. 2017 Apr 10;7(7):1875–1889. doi: 10.7150/thno.18985

Scheme 1.

Scheme 1

Schematic design of the self-assembly of gold nanoparticles. A) Gold nanoparticles self-assemble into nanospheres via cross-linking with dithiol-polyethylene glycol (HS-PEG-SH) that are further modified with drug and EGF peptide. B) The nanoassemblies show the EPR effect and active targeting in brain tumors. Acidic and redox environments in tumors can mediate dynamic structural switching and controlled drug release.