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. 2017 May 2;7(7):1953–1965. doi: 10.7150/thno.16478

Figure 5.

Figure 5

miR-708 improved heart function in vivo. A and B: A swimming test at day 9 demonstrated the ISO-treated mice had shorter swimming time within 3 min (A) and shorter swimming time before first break (B), compared to PBS control mice. miR-708 therapy improved significantly the swimming ability of the ISO-treated mice. C: miR-708 therapy decreased the ratios of heart weight to body weight and heart weight to tibia length in the ISO-treated mice. D: WGA staining showing the cardiomyocyte hypertrophy induced by ISO, which can be partly rescued by miR-708 treatment. E: Quantitative analysis of D. F: Masson's Trichrome Staining demonstrated the myocardial fibrosis induced by ISO, while miR-708 treatment protected the cardiomyocytes against fibrosis. G: Quantitative analysis of F. Data are presented as mean ± SEM (n≧3). *p<0.05, **p<0.01.