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. 2017 May 12;7(7):1990–2002. doi: 10.7150/thno.18136

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Biodistribution and in vivo gene-silencing efficacy. (a) Ex vivo fluorescence image of the tumor and major organs from athymic nude mice bearing Luc-HeLa tumor treated with naked DY677-siRNA vs. NP (DY677-siRNA) with different lipid-PEGs. (b) Quantitative analysis of biodistribution of NP (siRNA) in different tissues and the Luc-HeLa tumor (n=3). (c) In vivo bioluminescence imaging of mice bearing Luc-HeLa tumor following IV injection of free siLuc or NP (siLuc) for 3 consecutive days. Images were taken at 5 min after intraperitoneal injection of 2 mg of D-Luciferin per mouse. (d) Luciferase expression in the protein extracts of tumor tissue treated with NP (siLuc) vs. naked siLuc (n=4, * p<0.05 vs. naked siRNA).