Table 2.
Liver Histology Distribution by Glucose Status
| Liver histology | Normal glucose N=473 |
Prediabetesa N=158 |
Type 2 Diabetesb N=44 |
Total N=675 |
p-valuec |
|---|---|---|---|---|---|
| Steatosis Grade | 0.554 | ||||
| <33% | 125 (26.4%) | 39 (24.7%) | 10 (22.7%) | 174 (25.8%) | |
| 34–66% | 155 (32.8%) | 43 (27.2%) | 14 (31.8%) | 212 (31.4%) | |
| >66% | 193 (40.8%) | 76 (48.1%) | 20 (45.5%) | 289 (42.8%) | |
| Lobular Inflammation | 0.178 | ||||
| < 2 under 20x | 271 (57.3%) | 75 (47.5%) | 23 (52.3%) | 369 (54.7%) | |
| 2–4 under 20x | 174 (36.8%) | 71 (44.9%) | 16 (36.4%) | 261 (38.7%) | |
| > 4 under 20x | 28 (5.9%) | 12 (7.6%) | 5 (11.4%) | 45 (6.7%) | |
| Ballooning | <.001 | ||||
| None | 282 (59.6%) | 77 (48.7%) | 13 (29.5%) | 372 (55.1%) | |
| Few | 128 (27.1%) | 49 (31.0%) | 19 (43.2%) | 196 (29.0%) | |
| Many | 63 (13.3%) | 32 (20.3%) | 12 (27.3%) | 107 (15.9%) | |
| Diagnosis | <.001 | ||||
| NAFLD, not NASH | 134 (28.3%) | 39 (24.7%) | 7 (15.9%) | 180 (26.7%) | |
| Borderline NASH: Zone 3 pattern | 81 (17.1%) | 23 (14.6%) | 13 (29.5%) | 117 (17.3%) | |
| Borderline NASH: Zone 1, periportal pattern | 154 (32.6%) | 42 (26.6%) | 5 (11.4%) | 201 (29.8%) | |
| Definite NASH | 104 (22.0%) | 54 (34.2%) | 19 (43.2%) | 177 (26.2%) | |
| Fibrosis Stage | N=471 | N=157 | N=43 | N=671 | 0.035 |
| 0: None | 146 (31.0%) | 48 (30.6%) | 10 (23.3%) | 204 (30.4%) | |
| 1a: Mild, zone 3 perisinusoidal | 33 (7.0%) | 7 (4.5%) | 7 (16.3%) | 47 (7.0%) | |
| 1b: Moderate, zone 3 perisinusoidal | 20 (4.2%) | 8 (5.1%) | 5 (11.6%) | 33 (4.9%) | |
| 1c: Portal/periportal only | 137 (29.1%) | 41 (26.1%) | 9 (20.9%) | 187 (27.9%) | |
| 2: Zone 3 and periportal | 59 (12.5%) | 33 (21.0%) | 8 (18.6%) | 100 (14.9%) | |
| 3: Bridging | 67 (14.2%) | 19 (12.1%) | 3 (7.0%) | 89 (13.3%) | |
| 4: Cirrhosis | 9 (1.9%) | 1 (0.6%) | 1 (2.3%) | 11 (1.6% |
Abbreviations: NAFLD= nonalcoholic fatty liver disease, NASH= nonalcoholic steatohepatitis.
a
Prediabetes defined as 1) fasting serum glucose between 100 mg/dL and 125 mg/dL; or 2) HbA1c ≥ 5.7 % and < 6.5 %.
b
Type 2 diabetes defined as 1) fasting serum glucose ≥ 126 mg/dL; 2) HbA1C ≥ 6.5%; or 3) existing clinical diagnosis of type 2 diabetes.
c
p-values are calculated based on F-test for continuous variables, and a X2 test for categorical variables.