Table II.

AFB₁ DNA adducts and translocation frequencies in rad4 mutants expressing CYP1A2 or CYP3A4

Straina	Plasmid	Spont. Frequency (x 10−7)	Induced Frequencyb (x 10−7)	Viabilityc	Fold inductiond	AFB1 DNA adducts (pmol/mg DNA)e
YB428	pRS424-CYP1A2	0.5 ± 0.2	13 ± 7	51%	29	3.4
YB437	pMA91-CYP3A4	1.6 ± 1.3	21± 14	44%	5.6	26.2

^aFor complete genotype, see Table I

^bAfter exposure to 50 μM AFB₁, His⁺ colonies/Total colony forming unit (CFU), N ≥ 2

^cCFU after exposure to AFB₁ / CFU without exposure × 100%

^dFrequency after AFB₁ exposure (Induced Frequency)/Frequency before exposure (Spont. Frequency)

^eN = 2