Table 2. Distribution of genotype and allele frequencies of MFN2 gene polymorphisms in acute liver failure patients and healthy participants.
| SNP | SNP/Genotype/Allele | Control group (n=160) | Case group (n=138) | P | OR | 95%CI |
|---|---|---|---|---|---|---|
| rs873457 | ||||||
| Genotype | GG | 32 (20.0%) | 35 (25.4%) | 1 (Ref.) | ||
| GC | 65 (40.6%) | 76 (55.1%) | 0.822 | 1.069 | 0.596-1.195 | |
| CC | 63 (39.4%) | 27 (19.5%) | 0.005 | 0.392 | 0.203-0.757 | |
| Allele | G | 129 (40.3%) | 146 (52.9%) | 1 (Ref.) | ||
| C | 191 (59.7%) | 130 (47.1%) | 0.002 | 0.601 | 0.434-0.833 | |
| rs2336384 | ||||||
| Genotype | GG | 34 (21.3%) | 36 (26.1%) | 1 (Ref.) | ||
| GT | 72 (45.0%) | 75 (54.3%) | 0.955 | 0.984 | 0.557-1.739 | |
| TT | 54 (33.7%) | 27 (19.6%) | 0.019 | 0.458 | 0.237-0.888 | |
| Allele | G | 140 (43.7%) | 147 (53.3%) | 1 (Ref.) | ||
| T | 180 (56.3%) | 129 (46.7%) | 0.021 | 0.683 | 0.494-0.943 | |
| rs1474868 | ||||||
| Genotype | AA | 29 (18.1%) | 35 (25.4%) | 1 (Ref.) | ||
| AG | 77 (48.1%) | 75 (54.3%) | 0.473 | 0.807 | 0.449-1.450 | |
| GG | 54 (33.8%) | 28 (20.3%) | 0.013 | 0.43 | 0.220-0.841 | |
| Allele | A | 135 (42.2%) | 145 (52.5%) | 1 (Ref.) | ||
| G | 185 (57.8%) | 131 (48.9%) | 0.012 | 0.659 | 0.478-0.912 | |
| rs4846085 | ||||||
| Genotype | TT | 31 (19.4%) | 38 (27.5%) | 1 (Ref.) | ||
| TC | 80 (50.0%) | 75 (54.3%) | 0.356 | 0.765 | 0.433-1.352 | |
| CC | 49 (30.6%) | 25 (18.2%) | 0.01 | 0.416 | 0.212-0.819 | |
| Allele | T | 142 (44.4%) | 151 (54.7%) | 1 (Ref.) | ||
| C | 178 (55.6%) | 125 (45.3%) | 0.012 | 0.66 | 0.478-0.913 | |
| rs4240897 | ||||||
| Genotype | AA | 29 (18.1%) | 30 (21.7%) | 1 (Ref.) | ||
| AG | 85 (53.1%) | 81 (58.7%) | 0.786 | 0.921 | 0.508-1.669 | |
| GG | 46 (28.8%) | 27 (19.6%) | 0.11 | 0.567 | 0.283-1.140 | |
| Allele | A | 143 (44.7%) | 141 (51.1%) | 1 (Ref.) | ||
| G | 177 (55.3%) | 135 (48.9%) | 0.119 | 0.774 | 0.560-1.068 | |
| rs2236055 | ||||||
| Genotype | AA | 27 (16.9%) | 35 (25.4%) | 1 (Ref.) | ||
| AG | 78 (48.8%) | 74 (53.6%) | 0.303 | 0.732 | 0.404-1.326 | |
| GG | 55 (34.4%) | 29 (21.0%) | 0.008 | 0.407 | 0.207-0.798 | |
| Allele | A | 136 (42.5%) | 144 (52.2%) | 1 (Ref.) | ||
| G | 188 (58.8%) | 132 (47.8%) | 0.013 | 0.663 | 0.480-0.916 | |
| rs873458 | ||||||
| Genotype | TT | 20 (12.5%) | 24 (17.4%) | 1 (Ref.) | ||
| TC | 79 (49.4%) | 67 (48.6%) | 0.314 | 0.707 | 0.359-1.391 | |
| CC | 61 (38.1%) | 47 (34.0%) | 0.217 | 0.642 | 0.317-1.300 | |
| Allele | T | 119 (37.2%) | 115 (41.5%) | 1 (Ref.) | ||
| C | 201 (62.8%) | 161 (58.5%) | 0.264 | 0.829 | 0.596-1.153 | |
SNP: single nucleotide polymorphism; OR: Odds ratio; CI: confidence interval. Statistical analysis was carried out with the chi-square test.