Table 2. Minimum inhibitory concentrations (MIC) of clinical isolates of Candida (n=130) to various antifungal drugs.
Antifungal | MIC range (μg/mL)* | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
0.065 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | |
Fluconazole | |||||||||||
C. albicans | 84 | 4 | 4 | 10 | 1 | 6 | |||||
C. glabrata | 5 | 3 | 1 | 2 | |||||||
C. tropicalis | 5 | 2 | 2 | ||||||||
C. dubliniensis | 2 | ||||||||||
Voriconazole | |||||||||||
C. albicans | 96 | 4 | 1 | 4 | 1 | 1 | 2 | ||||
C. glabrata | 9 | 2 | |||||||||
C. tropicalis | 7 | 1 | 1 | ||||||||
C. dubliniensis | 2 | ||||||||||
Caspofungin | |||||||||||
C. albicans | 102 | 3 | 4 | 4 | |||||||
C. glabrata | 9 | 2 | |||||||||
C. tropicalis | 6 | 2 | 1 | ||||||||
C. dubliniensis | 2 | ||||||||||
Micafungin | |||||||||||
C. albicans | 101 | 2 | 2 | 4 | |||||||
C. glabrata | 6 | 3 | 2 | ||||||||
C. tropicalis | 6 | 1 | 2 | ||||||||
C. dubliniensis | 2 | ||||||||||
Amphotericin B | |||||||||||
C. albicans | 72 | 31 | 2 | 4 | |||||||
C. glabrata | 3 | 6 | 2 | ||||||||
C. tropicalis | 6 | 1 | 2 | ||||||||
C. dubliniensis | 2 | ||||||||||
Flucytosine | |||||||||||
C. albicans | 103 | 2 | 2 | 2 | |||||||
C. glabrata | 7 | 3 | 1 | ||||||||
C. tropicalis | 6 | 1 | 1 | 1 | |||||||
C. dubliniensis | 2 |
MIC breakpoints' interpretation: fluconazole susceptible: MIC ≤8 µg/mL; fluconazole intermediate: MIC 16-32 µg/mL; fluconazole resistant: MIC ≥64 µg/mL; micafungin and caspofungin susceptible: MIC ≤0.25; micafungin and caspofungin intermediate: no clinical breakpoint; micafungin and caspofungin resistant: MIC ≥1 µg/mL; flucytosine susceptible: MIC ≤4 µg/mL; flucytosine intermediate: MIC 8-16 µg/mL; flucytosine resistant: MIC ≥32 µg/mL; voriconazole susceptible: MIC ≤1 µg/mL; voriconazole intermediate: MIC 2 µg/mL; voriconazole resistant: MIC≥ 4 µg/mL; amphotericin B susceptible: MIC ≤1 µg/mL; amphotericin B Intermediate: no clinical breakpoint; amphotericin B resistant: MIC >1 µg/mL.