Skip to main content
. 2017 May 15;50(6):e5797. doi: 10.1590/1414-431X20175797

Table 2. Minimum inhibitory concentrations (MIC) of clinical isolates of Candida (n=130) to various antifungal drugs.

Antifungal MIC range (μg/mL)*
0.065 0.125 0.25 0.5 1 2 4 8 16 32 64
Fluconazole
C. albicans 84 4 4 10 1 6
C. glabrata 5 3 1 2
C. tropicalis 5 2 2
C. dubliniensis 2
Voriconazole
C. albicans 96 4 1 4 1 1 2
C. glabrata 9 2
C. tropicalis 7 1 1
C. dubliniensis 2
Caspofungin
C. albicans 102 3 4 4
C. glabrata 9 2
C. tropicalis 6 2 1
C. dubliniensis 2
Micafungin
C. albicans 101 2 2 4
C. glabrata 6 3 2
C. tropicalis 6 1 2
C. dubliniensis 2
Amphotericin B
C. albicans 72 31 2 4
C. glabrata 3 6 2
C. tropicalis 6 1 2
C. dubliniensis 2
Flucytosine
C. albicans 103 2 2 2
C. glabrata 7 3 1
C. tropicalis 6 1 1 1
C. dubliniensis 2
*

MIC breakpoints' interpretation: fluconazole susceptible: MIC ≤8 µg/mL; fluconazole intermediate: MIC 16-32 µg/mL; fluconazole resistant: MIC ≥64 µg/mL; micafungin and caspofungin susceptible: MIC ≤0.25; micafungin and caspofungin intermediate: no clinical breakpoint; micafungin and caspofungin resistant: MIC ≥1 µg/mL; flucytosine susceptible: MIC ≤4 µg/mL; flucytosine intermediate: MIC 8-16 µg/mL; flucytosine resistant: MIC ≥32 µg/mL; voriconazole susceptible: MIC ≤1 µg/mL; voriconazole intermediate: MIC 2 µg/mL; voriconazole resistant: MIC≥ 4 µg/mL; amphotericin B susceptible: MIC ≤1 µg/mL; amphotericin B Intermediate: no clinical breakpoint; amphotericin B resistant: MIC >1 µg/mL.