Table 3. Effect of salvianolic acid B (SAB) on the activities of renal inflammatory markers in experimental groups.
Group | NF-p65 (pg/mg protein) | IL-1β (ng/mg protein) | IL-6 (pg/mg protein) | TNF-α (ng/mg protein) |
---|---|---|---|---|
Sham control | 95.82 ± 9.12 | 81.55 ± 9.81 | 91.39 ± 8.67 | 98.86 ± 10.32 |
IR | 211.35 ± 23.93a ** | 198.34 ± 16.13a ** | 232.38 ± 31.24a ** | 272.13 ± 21.45a ** |
SAB 20 + IR | 125.85 ± 10.01b ** | 121.83 ± 12.93b ** | 136.67 ± 12.62b ** | 167.13 ± 18.23b ** |
SAB 40 + IR | 101.45 ± 12.83b ** c * | 96.94 ± 9.56b ** c * | 112.43 ± 11.73b ** c * | 130.11 ± 12.44b * c * |
Data are reported as means±SD for 10 rats in each group.
P<0.05,
P<0.01
IR group compared to the sham control group;
treatment groups (SAB 20 and 40 mg·kg−1·day−1) compared to the IR insulted group;
SAB 40 group compared to the SAB 20 group (ANOVA). IR: ischemic reperfusion; NF-p65: nuclear factor p65 subunit; IL-1β: interleukin 1β; IL-6: interleukin 6; TNF-α: tumor necrotic factor α.