Figure 5. miR-455 inhibited proliferation and induced apoptosis of HCT116 cells. Cell viability (A) and cell apoptosis (B and C) of cells transfected with miR-NC or miR-455 mimics were measured by MTT assay and flow cytometry, respectively. Data are reported as the mean±SD of 3 independent experiments. *P<0.05; **P<0.01; ***P<0.001 (two-tailed unpaired t-test). MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HDAC2: histone deacetylase 2; miR-455 mimics: microRNA-455 mimics; miR-NC: negative control of miR-455.