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. 2017 May 18;50(6):e6104. doi: 10.1590/1414-431X20176104

Table 1. An overview of studies on the roles of matrix metalloproteinases (MMPs) in ovarian cancer published since 2010.

Author, year MMP molecule(s) Role in ovarian cancer
Pei et al., 2016 (28) MMP-2 and MMP-9 Bisdemethoxycurcumin inhibits ovarian cancer cells via reducing oxidative stress-mediated expression of MMP-2 and -9.
Wang et al., 2016 (27) MMP-2 and MMP-9 Fe-MIL-101 suppresses the proliferation of human SKOV3 ovarian cancer cells via downregulation the expression of MMP-2 and -9.
Vos et al., 2016 (37) MMP-14 Patients with double expression of MMP-14 and CD44 have a poor prognosis.
Fu et al., 2015 (11) MMP-2 Tumor-derived MMP-2 expression predicts a lower overall survival rate and could be an independent prognostic factor in patients with ovarian cancer.
Gonzalez-Villasana et al., 2015 (15) MMP-2 Zoledronic acid exerts robust inhibitory activity on cell invasion of HeyA8-MDR and OVCAR-5 ovarian cancer cells through decreasing the intracellular level of MMP-2.
Liu etal., 2015 (33) MMP-12 MMP-12 82 A/G polymorphism increases the susceptibility to ovarian cancer despite not being significantly associated with overall cancer risk.
Chen et al., 2015 (32) MMP-12 MMP-12 82 A/G polymorphism is a genetic risk factor for epithelial ovarian carcinoma.
Gao et al., 2014 (14) MMP-2 Catalpol suppresses proliferation and accelerated apoptosis of OVCAR-3 ovarian cancer cells via promoting microRNA-200 expression and reducing MMP-2 signaling.
Bandaru et al., 2014 (26) MMP-9 Filamin B (FLNB) suppresses the growth and metastasis of human ovarian cancer by down-regulating the activity of MMP-9 and secretion of vascular endothelial growth factor-A (VEGF-A).
Trudel et al., 2014 (36) MMP-14 Higher expression of MMP-14 is associated with lower progression and better prognosis of ovarian carcinoma.
Wang et al., 2013 (10) MMP-2 MMP-2 plays a positive role in the invasion and metastasis of ovarian cancer.
Al-Alem et al., 2013 (30) MMP-7 and MMP-10 Targeted inhibition of MMP-7 and MMP-10 may provide potential ovarian cancer therapeutic strategy.
Li et al., 2013 (25) MMP-9 Increased expression of MMP-9 is associated with poor prognosis in ovarian cancer.
Kaimal et al., 2013 (38) MMP-14 MMP-14-dependent invasion and metastasis is effectively inhibited by intraperitoneal administration of monoclonal MMP-14 antibody.
Zhao et al., 2012 (21) MMP-7 Triptolide inhibits the migration and invasion of ovarian cancer cells by suppression of MMP-7.
Chang et al., 2012 (19) MMP-7 Mesothelin enhances ovarian cancer invasion by MMP-7 expression through the MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) signal transduction pathways.
Ghosh et al., 2012 (34) MMP-9 and MMP-13 Activation of PI3K/AKT (phosphatidylinositol-3-kinase) and p38 MAPK by VEGF activates MMP-9 and MMP-13, leading to the invasion of SKOV-3 cells.
Agarwal et al., 2010 (4) MMP-1 MMP-1-PAR1 (protease-activated receptor-1) activation induces secretion of several angiogenic factors in ovarian carcinoma cells, leading to cell proliferation, tube formation and migration.