Figure 25.

Visualizations of protein-ligand complexes with binding affinity data for point mutations in the protein. The top three most significant changes in binding affinity from the Platinum database are shown from left to right. Any residue that was mutated experimentally is shown in stick form, while the rest of the protein is shown as a cartoon. In all three cases, the green coloring supports the experimental results that the residues in question are important for ligand binding. Visualization is performed using the 2:1 DUD-E/CSAR model.