TABLE 2.
Summary of Pathologic Tumor Volume, Apparent Diffusion Coefficient (ADC) Value From DWI, and Volume Transfer Constant (Ktrans) Value From Dynamic Contrast-Enhanced MRI, as Stratified by Gleason Score (GS)
| GS | Tumor Volume (mL) | ADC Value (× 10−3 mm2/s) | Ktrans Value (min−1) | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| No. of Patients | Median (Range) | p | No. of Patients | Median (Range) | p | No. of Patients | Median (Range) | p | |
|
| |||||||||
| 3 + 3 | 34 | 0.88 (0.50–5.68) | Reference | 30 | 0.98 (0.70–1.23) | Reference | 34 | 0.21 (0.03–0.54) | Reference |
| 3 + 4 | 113 | 1.54 (0.50–29.56) | 0.021 | 101 | 0.88 (0.54–1.47) | 0.003 | 107 | 0.21 (0.03–0.62) | 0.778 |
| 4 + 3 | 30 | 3.07 (0.50–17.59) | < 0.001 | 28 | 0.84 (0.64–1.17) | < 0.001 | 28 | 0.25 (0.13–0.56) | 0.015 |
| 4 + 4 or higher | 18 | 2.70 (0.71–30.87) | < 0.001 | 17 | 0.77 (0.55–0.97) | < 0.001 | 15 | 0.31 (0.19–0.90) | < 0.001 |
|
| |||||||||
| All | 195 | 1.60 (0.50–30.87) | < 0.001 | 176 | 0.89 (0.54–1.47) | < 0.001 | 184 | 0.22 (0.03–0.90) | 0.001 |
Note—Statistical significance of the differences between the GS groups is denoted by p values. ADC values for tumors with a GS of 3 + 3 differed significantly from those of tumors with GSs in all other categories; however, Ktrans values of tumors with a GS of 3 + 3 differed significantly only from those of tumors with a primary Gleason grade of 4.