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. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: AJR Am J Roentgenol. 2016 Feb 22;206(4):756–763. doi: 10.2214/AJR.15.14912

TABLE 5.

Estimated Sensitivities and Specificities (Including 95% CIs and Thresholds) for Apparent Diffusion Coefficient (ADC) Value, Forward Volume Transfer Constant (Ktrans) Value, and the Combination of Both Parameters in Differentiating Between Different Gleason Scores (GSs)

GS, Variable Sensitivity (95% CI) Specificity (95% CI) Threshold
3 + 3 vs 3 + 4 or higher
 Median ADC value 0.547 (0.329–0.841) 0.800 (0.500–0.956) 0.888 × 10−3 mm2/s
 Median Ktrans value 0.445 (0.382–0.864) 0.800 (0.364–0.907) 0.248 min−1
3 + 4 or lower vs 4 + 3 or higher
 Median ADC value 0.488 (0.406–0.960) 0.778 (0.331–0.874) 0.792 × 10−3 mm2/s
 Median Ktrans value 0.780 (0.652–0.920) 0.627 (0.548–0.723) 0.229 min−1
 Both 0.902 (0.500–0.963) 0.492 (0.442–0.890) 4591.90 × ADC − 6.76 × Ktrans = 2.70
4 + 3 or lower vs 4 + 4 or higher
 Median ADC value 0.714 (0.546–1.000) 0.634 (0.298–0.852) 0.84 × 10−3 mm2/s
 Median Ktrans value 0.857 (0.613–1.000) 0.660 (0.526–0.913) 0.252 min−1
 Both 0.929 (0.667–1.000) 0.647 (0.598–0.957) 7703.71 × ADC − 10.45 × Ktrans = 3.70