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. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: Biochemistry. 2016 Apr 4;55(15):2197–2213. doi: 10.1021/acs.biochem.5b01354

Figure 4.

Figure 4

Deuterium-exchange profiles for conformation-dependent antibody epitopes. (A) Indication of 17b or 48d,94 A32, or N5i542,62,95 epitopes on the gp120 monomer (PDB entry 4NCO). The CD4-binding site21,52 is targeted by CD4-binding antibodies, including VRC01,12 VRC03,67 F105,68 and b12.73 The peptides detected in H/D exchange, which cover the epitopes, are colored. (B–I) Individual deuterium uptake profiles for selected peptides positioned at conformation-dependent antibody epitopes. HXB2 numbering is applied for the primary sequence.