Table 1. Anthropometric and metabolic characteristics of the study subjects stratified according to tertiles of plasma kisspeptin values.
| Whole cohort | Tertile 1 | Tertile 2 | Tertile 3 | P | ||||
|---|---|---|---|---|---|---|---|---|
| (1) | (2) | (3) | 1 vs 2 | 1 vs 3 | 2 vs 3 | |||
| Kisspeptin (ng/ml) | 0.92±0.76 | 0.33±0.07 | 0.62±0.14 | 1.8±0.71 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Gender (Male/Female) | 137/124 | 43/44 | 48/39 | 46/41 | 0.74 | 0.54 | 0.76 | 0.88 |
| Age (years) | 47.7±13.2 | 43.4±13.6 | 48.5±13.4 | 51.4±11.2 | <0.0001 | 0.01 | <0.0001 | 0.13 |
| BMI (kg/m2) | 30.1±7.6 | 30.7±8.9 | 30.8±8.1 | 28.4±4.8 | 0.15a | 0.72 a | 0.14 a | 0.06a |
| Waist circumference (cm) | 101.9±17 | 102±19 | 104±18 | 98±12 | 0.06 a | 0.36 a | 0.16 a | 0.02 a |
| Systolic blood pressure (mmHg) | 128±17 | 124±17 | 128±15 | 131±17 | 0.16 | 0.60 | 0.06 | 0.16 |
| Diastolic blood pressure (mmHg) | 79±10 | 76±10 | 79±10 | 82±10 | 0.006 | 0.20 | 0.002 | 0.04 |
| Total cholesterol (mg/dl) | 198±37 | 198±36 | 196±35 | 200±39 | 0.67 | 0.38 | 0.78 | 0.55 |
| HDL (mg/dl) | 51±14 | 51±13 | 51±15 | 51±13 | 0.68 | 0.70 | 0.63 | 0.38 |
| Triglycerides (mg/dl) | 122±72 | 114±55 | 122±74 | 127±82 | 0.62 | 0.91 | 0.44 | 0.36 |
| Fasting Glucose (mg/dl) | 97±14 | 95±13 | 97±13 | 99±14 | 0.70 | 0.87 | 0.43 | 0.51 |
| 2-h post-load glucose (mg/dl) | 131±37 | 124±36 | 131±33 | 136±40 | 0.53 | 0.90 | 0.30 | 0.35 |
| Glucose tolerance status (NGT/IGT) | 159/102 | 55/32 | 54/33 | 50/37 | 0.71 | 0.88 | 0.53 | 0.63 |
| Fasting Insulin (μU/ml) | 11±6 | 11±6 | 11±8 | 9±4 | 0.61 | 0.54 | 0.73 | 0.33 |
| IGF-1(ng/ml) | 164±59 | 170±63 | 164±59 | 158±54 | 0.80 | 0.80 | 0.68 | 0.51 |
| Matsuda insulin sensitivity index (mg x L2 x mmol-1 x mU-1 x min-1) | 81±46 | 80±46 | 76±47 | 86±44 | 0.88 | 0.73 | 0.87 | 0.62 |
Data are means ± SD. Insulin, triglycerides and hsCRP levels were log transformed for statistical analysis, but values in the table represent a back transformation to the original scale. Categorical variables were compared by χ2 test. Comparisons among the three groups were performed using a general linear model. P values refer to results after analyses with adjustment for age, gender, and BMI; aP values refer to results after analyses with adjustment for age, and gender. BMI = body mass index; HDL = high density lipoprotein; NGT = normal glucose tolerance; IGT = impaired glucose tolerance;IGF-1 = insulin-like growth factor 1.