Table 3. Univariate correlations between kisspeptin concentration and anthropometric and metabolic variables.
Whole study group | Subjects with NGT (N = 159) | Subjects with IGT (N = 102) | ||||
---|---|---|---|---|---|---|
Kisspeptin | Kisspeptin | Kisspeptin | ||||
r | P | r | P | r | P | |
Age (years) | 0.18 | 0.007 | 0.17 | 0.01 | 0.07 | 0.22 |
BMI (kg/m2) | -0.12 | 0.04 | -0.13 | 0.04 | -0.11 | 0.11 |
Waist circumference (cm) | -0.12 | 0.04 | -0.10 | 0.10 | -0.13 | 0.08 |
Systolic blood pressure (mmHg) | 0.09 | 0.09 | 0.07 | 0.16 | 0.05 | 0.30 |
Diastolic blood pressure (mmHg) | 0.17 | 0.007 | 0.15 | 0.02 | 0.10 | 0.16 |
Total cholesterol (mg/dl) | 0.08 | 0.10 | 0.03 | 0.36 | 0.12 | 0.11 |
HDL cholesterol (mg/dl) | -0.01 | 0.48 | -0.06 | 0.19 | -0.13 | 0.09 |
Triglycerides (mg/dl) | 0.07 | 0.15 | 0.10 | 0.09 | 0.06 | 0.29 |
Fasting glucose (mg/dl) | 0.07 | 0.14 | 0.05 | 0.27 | 0.01 | 0.49 |
2-h glucose (mg/dl) | 0.12 | 0.03 | 0.12 | 0.06 | 0.01 | 0.49 |
Fasting insulin (μU/ml) | -0.10 | 0.06 | -0.16 | 0.02 | -0.01 | 0.37 |
IGF-1(ng/ml) | -0.09 | 0.10 | -0.10 | 0.11 | -0.04 | 0.34 |
Matsuda Insulin Sensitivity index (mg x L2 x mmol-1 x mU-1 x min-1) | 0.01 | 0.41 | 0.05 | 0.23 | 0.01 | 0.48 |
Insulinogenic index (ΔIns30/ΔGluc30)(μU/ml per mg/dl) | -0.24 | <0.0001 | -0.25 | 0.001 | -0.17 | 0.04 |
Stumvoll 1st phase index (pmol/l) | -0.21 | 0.001 | -0.22 | 0.003 | -0.16 | 0.05 |
Stumvoll 2nd phase index (pmol/l) | -0.20 | 0.002 | -0.21 | 0.004 | -0.15 | 0.05 |
CIR30 | -0.23 | <0.0001 | -0.25 | 0.001 | -0.16 | 0.05 |
Disposition index (ΔIns30/ΔGluc30 x Matsuda index) | -0.20 | 0.002 | -0.22 | 0.003 | -0.17 | 0.05 |
NGT = normal glucose tolerance; IGT = impaired glucose tolerance; BMI = body mass index; HDL = high density lipoprotein; IGF-1 = insulin-like growth factor 1; CIR30 = corrected insulin response.