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. Author manuscript; available in PMC: 2018 May 23.
Published in final edited form as: Biochemistry. 2017 Apr 14;56(20):2584–2593. doi: 10.1021/acs.biochem.7b00078

Table 1.

Ki values for Wild-type and Modified PTHR peptidesa

PDZ Peptide FP
Ki μM ΔG° kcal/mol
PDZ1 PTHRct-9 1.4 ± 0.9 −8.0 ± 0.5
PDZ1 PTHR-pThrct-9 121b −5.3
PDZ1 Cys-PTHRct-9 11.0b −6.7
a

determined by FP competition assay as detailed in Materials and Methods

b

single determination in triplicates