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. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: Nature. 2016 Sep 19;539(7629):437–442. doi: 10.1038/nature19834

Figure 3. Macrophage PI3Kγ suppresses T cell activation.

Figure 3

(a) Adoptive transfer method. (b) Weights of tumors implanted with p110γ−/−, WT or no TAMs (n=8). (c) CD8+ T cells from b (n=16). (d, e) Weights of tumors implanted with (d) in vitro cultured macrophages (n=8) or (e) macrophage-conditioned medium (CM) (n=8). (f) Percent T cells in WT and p110γ−/− tumors (n=3). (g) Tumor volumes in p110γ and/or CD8−/− mice (n=6). (h–i) Weights of tumors implanted with (h) naïve or tumor-derived T cells (n=8) or (i) inhibitor-treated T cells (n=16). (j) IFNγ and Granzyme B expression in tumors and T cells from WT and p110γ−/− animals (n=3). All graphs show mean +/− sem of biological replicates.