Figure 6.
Effects of AT1001 on colon weight, length, and histology in DSS-treated Ztm mice. (A) Histology scores showed a significant decrease in inflammatory score, with DSS + AT1001–treated mice showing scores similar to untreated mice. (B) Representative histology of colon of either DSS-treated or DSS + AT1001–treated Ztm showing complete rescue of the colitis secondary to AT1001 treatment. AT1001 also prevented the decrease in colon length (C) and weight (D) (4–14 mice per group). **, P < 0.01; ***, P < 0.001.