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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Toxicol In Vitro. 2017 Feb 27;41:75–82. doi: 10.1016/j.tiv.2017.02.019

Figure 5. Regulation of pro-inflammatory cytokine expression by Paclitaxel.

Figure 5

(A) Primary mouse hepatocytes from TLR4-wt mice were treated with 0.1% DMSO (vehicle) or 20 μM of paclitaxel for 4 h. (B) Primary mouse hepatocytes from TLR4-wt and mutant mice were treated with 0.1% DMSO (vehicle) or 20 μM of paclitaxel for 24 h. RNA was isolated from the livers and analyzed by real-time PCR. n = 3 per group. All data are presented as ± S.D. and standardized for cyclophilin mRNA levels. Expression in DMSO group was set to 1, fold change after paclitaxel treatment was compared to vehicle. (*) indicates significant difference (p < 0.05) between vehicle and paclitaxel groups; (#) indicates significant differences (p < 0.05) between paclitaxel treated samples of TLR4-wt and mutant groups. The experiments were repeated at least three times.