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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Mol Carcinog. 2017 Mar 6;56(7):1733–1742. doi: 10.1002/mc.22630

Figure 1.

Figure 1

Mutation screening of PhIP-induced skin tumors in the rat. Representative data from PCR-based single-strand conformation polymorphism analysis. (A-B) open arrows indicate bands that were sequenced and confirmed to harbor Hras or Tp53 mutations (see Table 1). (C) No shifted bands were detected for Ctnnb1 in skin tumors. Hatched box, positive control from a PhIP-induced rat colon tumor, in which the shifted band (solid arrow) was sequenced and confirmed to harbor a β-catenin mutation [17]. A random screening of non-shifted bands confirmed the wild-type status of Hras, Tp53, and Ctnnb1 in other skin tumor samples (data not shown).