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Summary of gene mutations in PhIP-induced skin tumors
| Gene | Codon | Mutation | Frequency | Substitution | Histopathology |
|---|---|---|---|---|---|
|
| |||||
| Hras | 12 | GGA→GAA | 2 | G12E | Squamous cell carcinoma |
| GGA→GTA | 1 | G12V | Sebaceous epithelioma | ||
| 61 | CAA→CAT | 2 | G61H | Squamous papilloma, basal cell carcinoma | |
| CAA→AAA | 2 | Q61K | Squamous cell carcinoma, sebaceous epithelioma | ||
| Tp53 | 174 | GGC→GCC | 2 | G174A | Sebaceous adenoma, sebaceous squamous cell carcinoma |
