Table 3.

The NGS results of our cohort.

ID	Sex	chr:posi	ref > alt	type	Gene name	Amino acid change	Codon change	Effect	Impact	Transcript Id	Cosmic id	Cosmic allele
1	F	11:92087139	C > T	SNP	FAT3	L621F	CTT/TTT	missense_variant	MODERATE	ENST00000298047	COSMIC1206618	p.L621F
		7:116339746	C > T	SNP	MET	S203F	TCT/TTT	missense_variant	MODERATE	ENST00000318493	COSMIC282765	p.S203Y
		17:16049843	C > T	SNP	NCOR1	R310H	CGT/CAT	missense_variant	MODERATE	ENST00000268712	COSMIC1216870	p.R310H
		14:81534648	A > T	SNP	TSHR	Y98F	TAC/TTC	missense_variant	MODERATE	ENST00000541158	COSMIC553821	p.Y98C
		5:112174682	CAAG > C	INDEL	APC	QE1131Q	CAAGAA/CAA	inframe_deletion	MODERATE	ENST00000508376	COSMIC13868	p.Q1131*
2	F	7:81336664	C > G	SNP	HGF	G520R	GGA/CGA	missense_variant	MODERATE	ENST00000222390	COSMIC79203	p.G520*
		17:7577551	C > A	SNP	TP53	G244C	GGC/TGC	missense_variant	MODERATE	ENST00000269305	COSMIC10941	p.G244S
3	M	3:178952088	A > G	SNP	PIK3CA	H1048R	CAT/CGT	missense_variant	MODERATE	ENST00000263967	COSMIC36289	p.H1048R
		3:178952085	A > G	SNP	PIK3CA	H1047R	CAT/CGT	missense_variant	MODERATE	ENST00000263967	COSMIC94987	p.H1047L
		17:7578416	C > A	SNP	TP53	V172F	GTT/TTT	missense_variant	MODERATE	ENST00000269305	COSMIC43955	p.V172I
4	F	17:7577085	C > T	SNP	TP53	E285K	GAG/AAG	missense_variant	MODERATE	ENST00000269305	COSMIC44388	p.E285*
5	M	7:55242464	AGGAATTAA-GAGAAGC > A	INDEL	EGFR	KELREA745K	AAGGAATTAA-GAGAAGCA/AAA	disruptive_inframe_deletion	MODERATE	ENST00000275493	COSMIC51504	p.K745_E746insIPVAIK
		17:7579419	A > AG	INDEL	TP53	P89P	CCC/CCCC	frameshift_variant	HIGH	ENST00000269305	COSMIC1735386	p.S90T
6	M	7:140481402	C > G	SNP	BRAF	G469A	GGA/GCA	missense_variant	MODERATE	ENST00000288602	COSMIC460	p.G469A
7	M	17:59876521	T > C	SNP	BRIP1	N427S	AAC/AGC	missense_variant	MODERATE	ENST00000259008	COSMIC3742356	p.N427S
		12:49426753	AGTTGCT > A	INDEL	KMT2D	QQL3910L	CAGCAACTT/CTT	disruptive_inframe_deletion	MODERATE	ENST00000301067	COSMIC1190862	p.Q3910_L3912 > H

chr: chromosome, posi: position, ref: reference genome, alt: gene alteration.