Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 21;7:3946. doi: 10.1038/s41598-017-03292-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Behavioural study in obese pre-diabetic mice acutely treated with LH-21. (A–D) Exploratory activity was recorded for ten minutes in the open field maze in control, 45% HFD-vehicle and 45% HFD-LH-21 mice. Entries into center (A), time in center (B), distance in center (C) and overall distance travelled (D) were monitored. No changes were detected between control and 45% HFD-vehicle mice. However, acute LH-21 injections increased exploratory activity in the center in 45% HFD mice, as assessed by increased time and distance travelled in center; (E–G) Anxiety was analysed by the elevated plus maze test in these mice. Entries into open arm (E), time in open arms (F) and distance travelled in open arms (G) were recorded for five minutes. 45% HFD-vehicle mice showed an anxiety-like behaviour with decreased time in open arms and distance travelled in open arms when compared to control mice. Acute injections of LH-21 in 45% HFD mice increased the number of entries into open arms and reverted the HFD-induced decrease in time in open arms and distance travelled in open arms. n = 8–10 mice each group. One-way ANOVA and Bonferroni’s post-test, *p < 0.05 versus control; ^#p < 0.05, ^##p < 0.01 versus 45% HFD-Vehicle.