Figure 5.
Waning anti-proliferative potency over-time modulates cure. Latent reservoir dynamics on combined ART and anti-proliferative therapy simulated for waning potency of anti-proliferative therapy over time. The latent reservoir size is shown with horizontal black lines corresponding to the cure threshholds used throughout the paper. Cure thresholds are achieved within 10 years if potency decreases by less than 5% per month considering 1% naïve T cells (L n(0)/L 0 = 0.01) and initial anti-proliferative potency ε AP = 5.