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. 2017 Jun 21;7:4014. doi: 10.1038/s41598-017-04256-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic profiles for neuroprotection by resveratrol and LiCl in 128Q nematodes. Data are mean ± SEM for > 200 nematodes in each group and a total of at least 4 independent experiments in all panels. ns: not significant. (A) Resveratrol is dependent on bar-1/ß-catenin, ucp-4/UCP and antioxidant enzymes for neuroprotection in C. elegans. Resveratrol protection is lost in bar-1/ß-catenin, ucp-4/UCP, ctl-2/catalase and sod-3/superoxide dismutase mutants. **P < 0.01 and ***P < 0.001 versus DMSO-treated 128Q animals. (B) LiCl sustains the function of 128Q nematode neurons in a manner that is partially dependent on daf-16/FOXO, with no effects detected in 19Q nematodes. *P < 0.05 and **P < 0.01 versus DMSO-treated 128Q animals.