Table 1.
Effect of steroids and FK506 on neuronal dysfunction of 128Q nematodes.
| Compound | Effect on 128Q cytotoxicity | Comment | ||
|---|---|---|---|---|
| Rmax, % | EC50, µM | ED50, µM | ||
| 17ßE2 | 17.4 ± 2.7 | 25 | n.a. | Protection |
| 2-MetoxyE2 | 6.8 ± 3.2 | n.a. | n.a. | No protection |
| 17aE2 | 6.5 ± 7.4 | n.a. | n.a. | No protection |
| MAP4343 | 21.3 ± 4.6 | n.a. | 50 | Protection |
| Pregenenolone | 2.5 ± 1.8 | n.a. | n.a. | No protection |
| Testosterone | 5.4 ± 1.6 | n.a. | n.a. | No protection |
| DHEA | 6.3 ± 3.1 | n.a. | n.a. | No protection |
| 3Me-D5A | 3.1 ± 1.9 | n.a. | n.a. | No protection |
| FK506 | 13.5 ± 3.1 | n.a. | n.a. | No protection |
Nematodes were scored for sensitivity to posterior touch at various compound concentrations (100–0.1 µM). The percentage of phenotypic (touch sensitivity) rescue at the most effective compound concentration relative to untreated 128Q nematodes is indicated as the Rmax. The EC50 is the half maximal effective concentration. The Rmax is the percentage of rescue at most effective concentration of drug relative to untreated control. The ED50 is the dose of a drug that is pharmacologically effective for 50% of the population. n.a.: not applicable (see shape of dose-response curve).