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. 2017 Jun 21;7:3945. doi: 10.1038/s41598-017-04233-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-throughput screening of Keap1-Nrf2-binding inhibitors. (A) Representative results of the FCS screening are shown. Known drugs in our chemical library were added individually to the mixed solution of Nrf2-ETGE and GST-Keap1-DGR. Nrf2-ETGE and GST-Keap1-DGR without the addition of test compounds was used as the negative control (NC, solvent control for binding state), and Nrf2-ETGE and GST-alone was used as the positive control (PC, dissociation control). White bars show the drugs with potential inhibitory effects on binding. (B) Flow chart of this drug screening project.