Table 2.

IC50 values for cell lines treated with various agents. (a) HER-family targeting TKIs and (b) other TKIs and chemotherapeutic agents.

a	IC50 Values (µM)
Cell Line	Erlotinib	Gefitinib	Lapatinib	Sapitinib	Afatinib	Neratinib	Canertinib
BT474	2.88	0.46	0.023	0.24	0.004	0.003	0.031
MCF7	>10	>10	2.66	6.73	1.55	0.35	1.60
MDA-MB-231	3.28	>10	9.29	>10	3.69	1.35	2.59
MDA-MB-453	>10	7.35	0.26	4.37	0.13	0.11	0.67
MDA-MB-468	5.71	1.73	1.73	6.57	0.82	0.036	1.51
SKBr3	1.06	4.50	0.015	0.20	0.003	0.003	0.011
T47D	9.21	8.82	2.87	1.91	0.89	0.86	1.41
b	IC 50 Values (µM)
Cell Line	NVP-AEW541	Dasatinib	Imatinib	Crizotinib	Paclitaxel	Gemcitabine
BT474	2.29	0.11	9.20	2.30	0.007	0.047
MCF7	0.14	4.95	>10	0.42	0.002	0.058
MDA-MB-231	2.84	0.009	9.46	1.09	0.024	1.389
MDA-MB-453	1.91	2.79	8.94	0.40	0.002	0.004
MDA-MB-468	1.57	0.087	5.44	0.76	0.003	0.003
SKBr3	3.80	4.17	9.45	4.61	0.002	0.35
T47D	5.27	0.067	8.38	1.16	0.001	0.38

Each value is the mean of triplicate samples.