Table 2.
a | IC50 Values (µM) | ||||||
---|---|---|---|---|---|---|---|
Cell Line | Erlotinib | Gefitinib | Lapatinib | Sapitinib | Afatinib | Neratinib | Canertinib |
BT474 | 2.88 | 0.46 | 0.023 | 0.24 | 0.004 | 0.003 | 0.031 |
MCF7 | >10 | >10 | 2.66 | 6.73 | 1.55 | 0.35 | 1.60 |
MDA-MB-231 | 3.28 | >10 | 9.29 | >10 | 3.69 | 1.35 | 2.59 |
MDA-MB-453 | >10 | 7.35 | 0.26 | 4.37 | 0.13 | 0.11 | 0.67 |
MDA-MB-468 | 5.71 | 1.73 | 1.73 | 6.57 | 0.82 | 0.036 | 1.51 |
SKBr3 | 1.06 | 4.50 | 0.015 | 0.20 | 0.003 | 0.003 | 0.011 |
T47D | 9.21 | 8.82 | 2.87 | 1.91 | 0.89 | 0.86 | 1.41 |
b | IC 50 Values (µM) | ||||||
Cell Line | NVP-AEW541 | Dasatinib | Imatinib | Crizotinib | Paclitaxel | Gemcitabine | |
BT474 | 2.29 | 0.11 | 9.20 | 2.30 | 0.007 | 0.047 | |
MCF7 | 0.14 | 4.95 | >10 | 0.42 | 0.002 | 0.058 | |
MDA-MB-231 | 2.84 | 0.009 | 9.46 | 1.09 | 0.024 | 1.389 | |
MDA-MB-453 | 1.91 | 2.79 | 8.94 | 0.40 | 0.002 | 0.004 | |
MDA-MB-468 | 1.57 | 0.087 | 5.44 | 0.76 | 0.003 | 0.003 | |
SKBr3 | 3.80 | 4.17 | 9.45 | 4.61 | 0.002 | 0.35 | |
T47D | 5.27 | 0.067 | 8.38 | 1.16 | 0.001 | 0.38 |
Each value is the mean of triplicate samples.