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. 2017 Jun 21;7:3989. doi: 10.1038/s41598-017-02801-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of KLF6-dependent, platelet-induced tumor cell proliferation. The platelet-induced proliferation of HCC cells requires platelet by the platelet-specific agonist CRP or HCC cells. Activated platelets then secrete granules containing cytokines, such as TGF-β, that promote tumor cell growth and mediate the cell cycle and apoptosis of tumor cells by down-regulation of KLF6 expression.